| Dose Level = 2500 mg/m2/day (twice daily 1250 mg/m2) |
Number of tablets to be taken at each dose (morning and evening) |
| Surface Area (m2) |
Total Daily
Dose(mg)* |
Twice Daily dose
(mg) |
150mg |
500mg |
| ≤ 1.25 |
3000 |
1500 |
- |
3 |
| 1.26–1.37 |
3300 |
1650 |
1 |
3 |
| 1.38–1.51 |
3600 |
1800 |
2 |
3 |
| 1.52–1.65 |
4000 |
2000 |
- |
4 |
| 1.66–1.77 |
4300 |
2150 |
1 |
4 |
| 1.78–1.91 |
4600 |
2300 |
2 |
4 |
| 1.92–2.05 |
5000 |
2500 |
- |
5 |
| 2.06–2.17 |
5300 |
2650 |
1 |
5 |
| ≥ 2.18 |
5600 |
2800 |
2 |
5 |
| * Total Daily Dose calculated on mg/m2 for the median value, and rounded to the nearest 100mg. |
| 75% Dose Level = 1900 mg/m2/day (twice daily 950 mg/m2) |
Number of tablets to be taken at each dose (morning and evening) |
| Surface Area (m2) |
Total Daily
Dose(mg)* |
Twice Daily dose
(mg) |
150mg |
500mg |
| ≤ 2 |
1.14 |
2000 |
1000 |
2 |
| 1.15 - 1.30 |
2300 |
1150 |
1 |
2 |
| 1.31 - 1.49 |
2600 |
1300 |
2 |
2 |
| 1.50 - 1.67 |
3000 |
1500 |
- |
3 |
| 1.68 - 1.83 |
3300 |
1650 |
1 |
3 |
| 1.84 - 2.02 |
3600 |
1800 |
2 |
3 |
| 2.03 – 2.21 |
4000 |
2000 |
- |
4 |
| ≥ 2.22 |
4300 |
2150 |
1 |
4 |
| * Total Daily Dose calculated on mg/m2 for the median value, and rounded to the nearest 100mg. |
| 50% Dose Level = 1250 mg/m2/day (twice daily 625 mg/m2) |
Number of tablets to be taken at each dose (morning and evening) |
| Surface Area (m2) |
Total Daily
Dose(mg)* |
Twice Daily dose
(mg) |
150mg |
500mg |
| 1.16 - 1.43 |
1600 |
800 |
2 |
1 |
| 1.44 - 1.71 |
2000 |
1000 |
- |
2 |
| 1.72 - 1.95 |
2300 |
1150 |
1 |
2 |
| 1.96 - 2.23 |
2600 |
1300 |
2 |
2 |
| ≥ 2.24 |
3000 |
1500 |
- |
3 |
| * Total Daily Dose calculated on mg/m2 for the median value, and rounded to the nearest 100mg. |
Last update: Tuesday, January 18, 2011
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